【作者】 許勝杰； 林文川； 林定威； 陳勁初；
【Author】 SHEU Senje 1,LIN Wenchuan2,LIN Tingwei1,CHEN Cinchu1 1Grape King Enterprises Corp.,Shanghai 201611,China;2School of Medicine,China Medical University,Taichung,Taiwan 40402,China
【機(jī)構(gòu)】 上海葡萄王企業(yè)有限公司； 中國(guó)醫(yī)藥大學(xué)醫(yī)學(xué)系；
【摘要】 為探討樟芝(Antrodia cinnamomea)發(fā)酵液凍干粉對(duì)CCl4誘發(fā)的大鼠慢性肝炎的作用,構(gòu)建CCl4誘發(fā)的大鼠慢性肝炎模型,結(jié)果表明處理6周時(shí)樟芝發(fā)酵液凍干粉可明顯降低血清谷草轉(zhuǎn)氨酶(glutamicoxaloacetic transaminase,GOT)、谷丙轉(zhuǎn)氨酶(glutamic pyruvic transaminase,GPT)的活性及白蛋白含量;第8周可增加血清白蛋白含量,明顯減輕脾臟重量,增加肝臟蛋白質(zhì)含量及降低肝臟含水量、脂質(zhì)過氧化程度和羥脯氨酸含量。因此,樟芝發(fā)酵液凍干粉可以減輕CCl4所誘發(fā)的大鼠慢性肝炎癥狀。
【Abstract】 The protective effects of powdered freeze-dried fermentation broth(FDFB),prepared from submerged cultures of Antrodia cinnamomea,against carbon tetrachloride(CCl4)-induced chronic hepatitis in rats are described.Doses of 20% CCl4(0.2 mL/100 g body weight) were administered to rats twice weekly(every Wednesday and Saturday) for eight consecutive weeks.Each rat was orally administered FDFB daily until the end of the experiment and one day prior to CCl4 administration.A significant decrease in elev...
【關(guān)鍵詞】 樟芝發(fā)酵液凍干粉； CCl4； 谷草轉(zhuǎn)氨酶； 谷丙轉(zhuǎn)氨酶；
【Key words】 Freeze-dried powder of Antrodia cinnamomea fermentation broth； carbon tetrachloride； glutamic oxaloacetic transaminase； glutamic pyruvic transaminase；
【分類號(hào)】S567.31