張利平; 陳彥; 王子堯; 祝慶軍
安徽大學(xué)生命科學(xué)院; 安徽醫(yī)科大學(xué)基礎(chǔ)醫(yī)學(xué)院

【中文摘要】 從羊肚菌發(fā)酵液中提取多糖并分析其基本生化特征,研究羊肚菌胞外多糖對小鼠免疫功能的影響。結(jié)果表明,羊肚菌多糖為蛋白多糖,其總糖含量為85.3%、蛋白含量為8.5%、酸性多糖含量為25%。該多糖可促進(jìn)小鼠胸腺指數(shù)和脾指數(shù)提升,增加血清溶菌酶含量,提高巨噬細(xì)胞吞噬能力,并能在體外促進(jìn)T淋巴細(xì)胞增殖及巨噬細(xì)胞NO量增加。作為一種蛋白多糖,羊肚菌多糖可以顯著增強(qiáng)小鼠的非特異性免疫及細(xì)胞免疫。

【英文摘要】 The effect of polysaccharides from Morchella esculenta (L.) Pers. (MEP) on immunological function was investigated. The results showed that MEP is a kind of proteoglycan. It has a total sugar of 85.3% and the protein level reached 8.5%. The content of alduronic acid in MEP is 25%. MEP can increase the level of thymus index and spleen index, the content of serum lysozyme, and can promote phagocytosis and NO level of macrophage. It can also enhance proliferation of T lymphocyte in vitro. As a proteoglycan, MEP can enhance nonspecific immunity and cellular immunity in mice.

【中文關(guān)鍵詞】 羊肚菌; 多糖; 免疫調(diào)節(jié); 巨噬細(xì)胞; 淋巴細(xì)胞
【英文關(guān)鍵詞】 Morchella esculenta (L.) Pers.; Polysaccharides; Immunological regulation; Macrophage; Lymphocyte
【基金】安徽省自然科學(xué)基金資助(No.070413143)

【文獻(xiàn)出處】 中國食用菌,Edible Fungi of China,編輯部郵箱,2009年03期 【DOI】CNKI:SUN:ZSYJ.0.2009-03-022