Intercalative Nanohybride of Cordycepin in Layered Double Hydroxide

Abstract：A novel negatively charged cordycepin-[Mg-Al-NO] nanohybrid has been prepared by ion-exchanged method.Results of TEM, PXRD and FT-IR spectroscopy confirmed that cordycepin could be intercalated into [Mg-Al-NO3] interlayers as the charge-compensating species.Preliminary result show that the new bioinorganic nanohybrid may be used as a novel inorganic pharmaceutically active compounds reservoir or carrier.b.

Keywords：cordycepin; layered double hydroxide; nanohybrid; intercalate

蟲(chóng)草素LDH插層納米復(fù)合體

楊親正　 羅珊珊　 凌建亞　 李彥　 張長(zhǎng)鎧　

摘　要：通過(guò)離子交換反應(yīng)制備了一種新型蟲(chóng)草素層狀雙氫氧化物納米復(fù)合體. 透射電鏡、X-衍射和紅外光譜分析結(jié)果表明,帶負(fù)電的蟲(chóng)草素中和無(wú)機(jī)層片電荷而插層到鎂鋁層狀雙氫氧化物[Mg-Al-NO3]中.實(shí)驗(yàn)結(jié)果顯示,通過(guò)簡(jiǎn)單的離子交換,可制得新型生物有機(jī)納米復(fù)合體,該類納米復(fù)合體將有可能成為生物活性分子的貯存庫(kù)或載體.

關(guān)鍵詞：蟲(chóng)草素; 層狀雙氫氧化物; 納米復(fù)合體; 插入

CLC Number：S567.3+5

Author Resume：Yang Qinzheng,mail,born in 1975,Ph.D..Address:State Key Laboratory of Microbial Technology, Shandong University, Jinan 250100.張長(zhǎng)鎧,Corresponding author

Author Unit：楊親正（山東大學(xué)微生物技術(shù)國(guó)家重點(diǎn)實(shí)驗(yàn)室,濟(jì)南,250100）　

　　　　　羅珊珊（山東大學(xué)微生物技術(shù)國(guó)家重點(diǎn)實(shí)驗(yàn)室,濟(jì)南,250100）　

　　　　　凌建亞（山東大學(xué)微生物技術(shù)國(guó)家重點(diǎn)實(shí)驗(yàn)室,濟(jì)南,250100）　

　　　　　李彥（山東大學(xué)微生物技術(shù)國(guó)家重點(diǎn)實(shí)驗(yàn)室,濟(jì)南,250100）　

　　　　　張長(zhǎng)鎧（山東大學(xué)微生物技術(shù)國(guó)家重點(diǎn)實(shí)驗(yàn)室,濟(jì)南,250100）　

References：

［1］Xu Z P , Zeng H C.Abrupt structural transformation in hydrotalcite-like compounds Mg1-xAlx(OH)2(NO3)x*nH2O as a continuous function of nitrate anio.J Phys Chem B ,2001, 105: 1743.

［2］Legrouri A , Badreddine M, Barroug A, et al. Influence of pH on the synthesis of the Zn-Al-nitrate layered double hydroxide and the exchange of nitrate by phosphate ions. J P Besse,J Mater Sci Lett,1999, 18:1077

［3］Choy J H, Kwak S Y , Park J S, et al.Intercalative nanohybrids of nucleoside monophosphates and DNA in layered metal hydroxide. J Am Chem Soc,1999,121:1399

［4］Zhao H T, Vance G F. Intercalation of carboxymethyl-cyclodextrin into magnesium-aluminum layered double hydroxide. J Chem Soc DaltonTrans,1997,11:1961

［5］Ahn Y J, Park S J ,Lee S G , et al. Cordycepin selective growth inhibitor derived from liquid culture of cordyceps militaris against clostridium spp. J Agric Food Chem,2000, 48:2744

［6］Suger A M ,Mccaffrey R P .Antifungal activity of 3'-deoxyadenosine (cordycepin). Agents Chemother, 1998, 42:1424

［7］Mueller W E G, Weiler B E, R, Charubala Ret al.Cordycepin analogues of 2'5'-oligoadenylate inhibit human immunodeficiency virus infection via inhibition of reverse transcriptase. Biochem Wash,1991, 30:2027

［8］Grahn B , Loevtrup-Rein H .The effect of cordycepin on nuclear RNA synthesis in nerve and glial cells. Acta Physiol Scand,1971, 82:28

［9］Yang Q Z , Zhan C G, Sun D J ,et al.Studies on Synthesis and Properties of Mg-Al-Nitrate Layered Double Hydroxide .Acta Chimica Sinica,2002, 9:1712

［10］Ling J Y , Sun Y J, Zhang H,et al.Measurement of cordycepin and adenosine in stroma of cordyceps sp. By capillary zone electrophoresis.J BiosBioe, 2002, 94:371

華中農(nóng)業(yè)大學(xué)學(xué)報(bào)

JOURNAL OF HUAZHONG AGRICULTURAL UNIVERSITY

2004 Vol.23 No.1